GATE 2014 Bio-Technology Syllabus
General Aptitude
1. Verbal Ability: English grammar, sentence completion, verbal analogies, word
groups, instructions, critical reasoning and verbal deduction.
2. Numerical Ability: Numerical computation, numerical estimation, numerical reasoning and data interpretation.
General Aptitude
1. Verbal Ability: English grammar, sentence completion, verbal analogies, word
groups, instructions, critical reasoning and verbal deduction.
2. Numerical Ability: Numerical computation, numerical estimation, numerical reasoning and data interpretation.
Engineering Mathematics :
Linear Algebra: Matrices and determinants, Systems of linear equations, Eigen values
and Eigen vectors.
Calculus: Limit, continuity and differentiability, Partial derivatives, Maxima and minima,
Sequences and series, Test for convergence, Fourier Series.
Differential Equations: Linear and nonlinear first order ODEs, higher order ODEs with
constant coefficients, Cauchy’s and Euler’s equations, Laplace transforms, PDE- Laplace,
heat and wave equations.
Probability and Statistics: Mean, median, mode and standard deviation, Random
variables, Poisson, normal and binomial distributions, Correlation and regression
analysis.
Numerical Methods: Solution of linear and nonlinear algebraic equations, Integration
of trapezoidal and Simpson’s rule, Single and multistep methods for differential
equations.
Biotechnology :
Microbiology: Prokaryotic and eukaryotic cell structure; Microbial nutrition, growth
and control; Microbial metabolism (aerobic and anaerobic respiration, photosynthesis);
Nitrogen fixation; Chemical basis of mutations and mutagens; Microbial genetics
(plasmids, transformation, transduction, conjugation); Microbial diversity and
characteristic features; Viruses.
Biochemistry: Biomolecules and their conformation; Weak inter-molecular interactions
in bio macromolecules; Chemical and functional nature of enzymes; Kinetics of single
substrate and bi-substrate enzyme catalyzed reactions; Bioenergetics; Metabolism
(Glycolysis, TCA and Oxidative phosphorylation); Membrane transport and pumps; Cell
cycle and cell growth control; Cell signaling and signal transduction.
Molecular Biology and Genetics: Molecular structure of genes and chromosomes; DNA
replication and control; Transcription and its control; Translational processes;
Regulatory controls in prokaryotes and eukaryotes; Mendelian inheritance; Gene
interaction; Complementation; Linkage, recombination and chromosome mapping;
Extrachromosomal inheritance; Chromosomal variation; Population genetics;
Transposable elements, Molecular basis of genetic diseases and applications.
Process Biotechnology: Bioprocess technology for the production of cell biomass and
primary/secondary metabolites, such as baker’s yeast, ethanol, citric acid, amino acids,
exo-polysacharides, antibiotics and pigments etc.; Microbial production, purification and
bioprocess application(s) of industrial enzymes; Production and purification of
recombinant proteins on a large scale; Chromatographic and membrane based
bioseparation methods; Immobilization of enzymes and cells and their application for
bioconversion processes.
Aerobic and anaerobic biological processes for stabilization of solid / liquid wastes;
Bioremediation.
Bioprocess Engineering: Kinetics of microbial growth, substrate utilization and
product formation; Simple structured models; Sterilization of air and media; Batch, fedbatch and continuous processes; Aeration and agitation; Mass transfer in bioreactors;
Rheology of fermentation fluids; Scale-up concepts; Design of fermentation media;
Various types of microbial and enzyme reactors; Instrumentation in bioreactors.
Plant and Animal Biotechnology: Special features and organization of plant cells; Tot
potency; Regeneration of plants; Plant products of industrial importance; Biochemistry
of major metabolic pathways and products; Autotrophic and heterotrophic growth;
Plant growth regulators and elicitors; Cell suspension culture development:
methodology, kinetics of growth and production formation, nutrient optimization;
Production of secondary metabolites by plant suspension cultures; Hairy root cultures
and their cultivation. Techniques in raising transgencies.
Characteristics of animal cells: Metabolism, regulation and nutritional requirements
for mass cultivation of animal cell cultures; Kinetics of cell growth and product
formation and effect of shear force; Product and substrate transport; Micro & macrocarrier culture; Hybridoma technology; Live stock improvement; Cloning in animals;
Genetic engineering in animal cell culture; Animal cell preservation.
Immunology: The origin of immunology; Inherent immunity; Humoral and cell
mediated immunity; Primary and secondary lymphoid organ; Antigen; B and T cells and
Macrophages; Major histocompatibility complex (MHC); Antigen processing and
presentation; Synthesis of antibody and secretion; Molecular basis of antibody diversity;
Polyclonal and monoclonal antibody; Complement; Antigen-antibody reaction;
Regulation of immune response; Immune tolerance; Hyper sensitivity; Autoimmunity;
Graft versus host reaction.
Recombinant DNA Technology: Restriction and modification enzymes; Vectors:
plasmid, bacteriophage and other viral vectors, cosmids, Ti plasmid, yeast artificial
chromosome; cDNA and genomic DNA library; Gene isolation; Gene cloning; Expression
of cloned gene; Transposons and gene targeting; DNA labeling; DNA sequencing;
Polymerase chain reactions; DNA fingerprinting; Southern and northern blotting; In-situ
hybridization; RAPD; RFLP; Site-directed mutagenesis; Gene transfer technologies; Gene
therapy.
Bioinformatics: Major bioinformatics resources (NCBI, EBI, ExPASy); Sequence and
structure databases; Sequence analysis (biomolecular sequence file formats, scoring
matrices, sequence alignment, phylogeny); Genomics and Proteomics (Large scale
genome sequencing strategies; Comparative genomics; Understanding DNA microarrays
and protein arrays); Molecular modeling and simulations (basic concepts including
concept of force fields).
A B.Tech Professional interested in Blogging. Wrote number of articles related to career.
ConversionConversion EmoticonEmoticon